In the instruction is said:"Cube 5x5x5 - it is the smallest cube that combines all the features of odd and even large cubes. Therefore, the principle of solving of the large blocks of Siamese is on the basis of solving Siamese cube 5x5x5."
(Beginning of the chapter 4).
Therefore safely apply algorithms of a cube 5х5х5 to a cube 4х4х4. Or use universal algorithm (U2 r')*5